Decoction of ban bian lian and its effective ingredients had protective effect on mice poisoned with cobra venom.

Decoction of ban bian lian and its effective ingredients had obvious respiration exciting effect on anaesthetized dogs, and the effect would strengthen and extend with the increase of dose. Death would be resulted from overdosage. Inhalation of lobeline could dilate bronchia and antagonize the bronchia contraction caused by pilocarpine and acetylcholine.

Intravascular injection of ban bian lian infusion had obvious and persistent blood pressure lowering effect on anaesthetized dogs. Decoction of ban bian lian iv at small dosage had temporary blood pressure lowering effect, while at large dosage, this effect was persistent. Alkaloids of ban bian lian had excitatory effect on isolated rabbit heart and frog heart, it strengthened the contractile force and increased the amplitude; at large dosage, there would be temporary excitement followed by inhibition, and finally conduction block and cardiac arrest. Intramuscular injection of lobeline could excite respiration, decrease the heart rate, increase the blood pressure, at large dosage, it could increase the heart rate and obviously lower the blood pressure, and finally lead to heart paralysis.

Intravenous injection of ban bian lian infusion at 0.1g/kg to anaesthetized dog, or gastrogavage of total alkaloids of ban bian lian at the dosage of 6.6mg/kg to rats, and oral administration of ban bian lian powder to people at the dosage for 10~30g, all had obvious and persistent diuretic effect, and the chloride output also increased in the urine. Intramuscular injection of lobeline also had diuretic effect on normal people, but the content of chloride didn't increase, or even decrease, and also with quite a few side effects.

Lobeline had similar effects on the nervous system to nicotine, but its strength was only equal to 1/5~1/20 of nicotine. It had excitatory effect followed by inhibitory effect on autonomic ganglia, adrenal medulla, nerve centers in medulla oblongata (especially vomiting center), neuromuscular junction, and chemoreceptors in the cartid artery and aorta.

Intravenous injection of 1g ban bian lian preparation obtained by water decoction and alcohol sedimentation (raw drug) to dogs could increase the bile by more than three folds, and the effect reached its peak at the 50th minutes after administration, but the contents of solids, cholate and cholerythrin all decreased to some extent in the bile.

Intramuscular injection of lobeline to cats or dogs could induce vomiting.

Oral administration of ban bian lian decoction could cause laxation. In vitro experiments showed that ban bian lian had inhibitory effect on staphylococcus aureus, bacillus typhosus, bacillus paratyphosus, shigella flexneri, bacillus coli and bacillus pyocyaneus.

ban bian lian, xia ku cao, bai hua she she cao, ban zhi lian, dan shen, xue jian chou of equal quanitiy were made into injections, 2 ml per bottle which contained 4g crude drug. Acu-injection to Yang Ling Quan (GB34, an acupoint on the leg) was applied daily or every other day. After the treatment, the survival time varied from 3 months to over 8 years. The survival rates 1, 3 , 5 years after treatment were 67.9%, 28.6%, and 7.1% respectively.

ban bian lian, tian nan xing, bai zhi, 12g each; ban xia 9g, xiong huang 6g, bing pain 3g. The drugs were made into paste with distilled spirit, or tea oil if with broken skin. Apply the paste onto the affected area, the symptoms got improved usually after 1 days, and greatly relieved and cured after 3 days

ban bian lian 30g, qing mu xiang, ju hua, bai zhi, ban xia, da haung, 10g each; jin yin hua, chi shao, 15g each; gan cao 3g. The patients were treated with 1~2 doses immediately after the bite, 1 dose since the second day. 31 cases of pallas pit viper bite were treated and all were cured after an average of 8 days.

Fresh ban bian lian 15g, water decoction and oral administration, 1 dose every day and taken in three times. This method was used to treat dysentery and got good results.

ban bian lian, shi wei, bai ma bian, che qian cao, shan bo luo, 30g each, yi dian hong, da ji, 20g each; gan cao 3g, one dose every day. 64 cases of acute nephritis were treated with this formula and all were cured.

Fresh ban bian lian were washed and smashed, then were applied to the swollen tissues around the open parts, the dressing was changed every 3~4 hours. 25 cases of acute phlegmon were treated, 9 of them were complicated with acute lymphangitis. Results: 22 cases were cured within 3 days, the other three cases were cured 1~2 days later.

Except those noted, all references come from Weng Weiliang, et al., Clinical Chinese materia medica, Henan Science & Technology Press, 1998