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Chuan Xin Lian - Andrographis paniculata
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Professional Data |
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 Pin Yin
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Chuan Xin Lian
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| Latin
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Herba Andrographitis
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| Introduction |
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Herba Andrographitis is the dried aerial part of Andrographis paniculata (Burm. f.) Nees (Fam. Acanthaceae). The drug is collected in early autumn when the plant is growing luxuriantly, and dried in the sun.
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| Western medical |
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The herb is indicated in the treatment of respiratory disorders and tumors.
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| Eastern medical |
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- Pattern: Clears Heat, removes Toxin, dries Dampness, stops diarrhea, treats strangury and purges Fire.
- Properties: Bitter, cold.
- Channels entered: Lung, Stomach, Large Intestine and Small Intestine.
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| Chemical constituents |
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The herb mainly contains andrographolide, deoxydandrographolide, 14-deoxy-11, 12-dideoxyhydro-andrographolide, 14-deoxy-11-oxoandrographolide, neoandrographolide, ninandrographolide, 19-glucosyl-deoxyandrographolide, deoxyandrographiside, andrographiside, 3, 4-dideoxyandrographolide, 14-deoxyandrographoside, andrographoside and homoandrographolide, etc..
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| Pharmacological actions |
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| Anti-pathogenic microorganism effect |
chuan xin lian had inhibitory effect on bacillus pyocyaneus, bacillus proteus, staphylococcus aureus, diplococcus pneumoniae, hemolytic streptococcus B, measles virus, influenza virus, shingles virus, Echo virus, tubercle bacillus, bacillus pertussis, leprae, and leptospira, etc.. |
| Anti-myocardial ischemia and anti-arrhythmia effects |
chuan xin lian could alleviate the injury caused by re-perfusion after acute myocardial ischemia. Its total flavones had anti-arrhythmia effect. |
| Anti-thrombus effect |
chuan xin lian extract could significantly inhibit the platelet aggregation induced by ADP and adrenalin (the influence was reversible); it also had obvious effect on platelet 5-HT release induced by ADP. |
| Influence over body onload="highlight();" immune function |
Water decoction of chuan xin lian could increase the staphylococcus aureus phagocytosis effect of WBC in vitro. Its preparation could elevate the serum bacteriolysin level, and increase the phagocytosis effect of celiac macrophages and neutrophilic granulocytes. |
| Anti-febrile and anti-inflammatory effects |
Andrographolide, deoxydandrographolide and other ingredients of chuan xin lian had atni-febrile and anti-inflammatory effects. |
| Influence over the pitutary-adrenal cortex |
Andrographolide, deoxydandrographolide, 14-deoxy-11, 12-dideoxyhydro-andrographolide and neoandrographolide at large doses could induce the atrophy of thymus gland juvenile mice, which indicates that the could increase the functions of adrenal cortex. |
| Effects on the central nervous system |
Yanning-3 and Chuan Hu Ning Injection had obvious sedative effect. |
| Effects on the liver and gallbladder |
Andrographolide had significant protecting effect on the liver injury caused by CCl4, D-chondrosamine and acamol. It could significantly lower the concentration of SGOT, SGPT, SALP, SBRN and HTG, etc.. chuan xin lian was also a cholagogue. |
| Anti-cancer effect |
chuan xin lian preparation at large, medium and small dosages all had inhibitory effect on the growth of tumor; the effect was dosage-dependen and stable. in vitro tests showed that chuan xin lian had inhibitory effect on cultured cancer 3H-TdR, which indicated that this herb may inhibit the synthsis of breast cancer cell. Dehydroandrograpolide succinate showed certain inhibitory effect on transplated W256 tumor. |
| Anti-pregnancy effect |
chuan xin lian had significant pregnancy-ceasing effect. |
| Others |
chuan xin lian had anti-snake venom effect.
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| Clinical Studies |
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| Respiratory tract infections |
chuan xin lian was made into tablets, each tablet containing 0.105g dry extract. 5 tablets, 3~4 times daily. The method could be used to treat sore throat, respiratory tract injections, acute tonsillitis, acute pharyngitis, acute laryngitis, influenza and acute bronchitis of Heat-Toxin or Externally contracted Wind-Heat type. |
| Tumors |
Chloroform or ethanol extract of chuan xin lian was made into injection of 5ml (each containing 0.05g extract), intramuslar injection, or loacal injection, 5ml. Bid. The method could be used to treat malignant mole and chorionepithelioma. |
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| References |
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Except those noted, all references come from Weng Weiliang, et al., Clinical Chinese materia medica, Henan Science & Technology Press, 1998 |
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