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Di Yu - Sanguisorba officinalis
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Professional Data |
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 Pin Yin
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Di Yu
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| Latin
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Radix Sanguisorbae
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| Introduction |
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Radix Sanguisorbae is the dried root of Sanguisorba officinalis L. or Sanguisorba officinalis L. var. longifolia (Bert.) Yu et Li (Fam. Rosaceae) The latter is commonly known as "Woolly Radix Sanguisorbae". The drug is collected in spring during budding or in autumn after withering, removed from rootlet, washed clean, dried; or cut into slices while fresh, and dried.
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| Western medical |
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The herb is used to treat primary thrombopenic purpura, nephritis, hemorrhage, uterine bleeding and skin diseases, etc..
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| Eastern medical |
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- Pattern: Cools Blood, stops bleeding, removes Toxin, astringes sores.
- Properties: Bitter, sour, cold.
- Channels entered: Liver, Stomach and Large Intestine.
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| Chemical constituents |
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di yu contains a large amount of tannin, and ziyuglycoside I, ziyuglycoside II, and sanguisorbin, etc..
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| Pharmacological actions |
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| Hemostatic effect |
Oral administration of decoction of parched di yu could significantly shorten the coagulation time in rabbits, intraperitoneal injection could shorten the bleeding time in mice. The mechanism was that di yu couldi ncrease the acitivity of platelet and inhibit the plasmin. |
| Effects on burn and scald |
di yu had significant therapeutic effect on II ~ III degree burn. Stirred di yu powder or formula containing di yu had good effects on scald or burn. |
| Anti-inflammatory effect |
di yu could inhibit the swelling in dorsum of the foot induced by formaldehyde and swollen ears induced by croton oil in mice. It had strong inhibitory effect on increased permeability of skin micrangium. It could inhibit the hyperplasia of granuloma induced by cotton ball in mice and promote the healing of the wound. It had anti-inflammatory and detumescent effects. |
| Antiemetic effect |
Decoction of di yu at the concentration of 3g/kg, bid for 4 times had antiemetic effect on pigeon for vomiting due to intravenous injection of foxglove. |
| Anti-bacterial effect |
di yu had in vtiro inhibitory effect on staphylococcus aureus, hemolytic streptococcus B, pneumococcus, bacilius diphtheriae, shigella dysenteriae, bacillus coli, typhoid bacillus, bacillus paratyphosus and bacillus pyocyaneus, etc.. It also had inhibitory effect to some pathogenic fungi. |
| Anti-tumor effect |
Hot water, ethanol or formic acid extract of di yu were administrated to S180 of ascitic type bearing male mice and the tumor inhibiting rate was 50%. in vitro tests showed that di yu had significant inhibitory effect on human cervical cancer JTC-26 strain. |
| Others |
Fresh Di Yu Injection could elevate WBC. Its decoction had regulatory effect on the cardiovascular system.
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| Clinical Studies |
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| Primary thrombopenic purpura |
Qing Huo Xiao Yu Tang: sheng di, shui niu jiao, bai mao gen, sheng shi gao, 30g each; di yu, dan pi, chi shao, dang gui, 12g each; xian he cao 20g; tu da huang 15g; gan cao 10g. The formula was used to treat primary thrombopenic purpura of Blood Heat type. The other type was treated with another formula. 1 dose every day, water decoction, for 1~3 months. 32 cases were treated, 14 markedly effective, 11 effective, 6 improved and 1 ineffective. |
| Nephritis due to purpura |
110 cases of nephritis due to purpura were treated with yu mi xue 30g; bai mao gen, xian he cao, 20g each; zi cao 12g; parched di yu, qian cao, dan pi, 9g each; shi wei, sheng di, huang qi, 15g each; san qi powder 3g (taken with water). 1 dose every day, water decoction. After 30~60 doses, all cases were cured and no recurrence was reported. |
| Hemorrhage of the upper digestive tract |
di yu was used in various formulas for the treatment of hemorrhage of the upper digestive tract, and it had good effect. |
| Necrotic enteritis |
bai tou weng, bai jiang cao, 15g each; da huang 10g; huai hua 12g; zhi shi, dan shen, bai shao, hou po, 9g each; pu gong ying 25g; di yu, huang lian, huang qin, 6g each; hong hua 3g. 1 dose every day, water decoction. The formula was used to treat 23 cases of necrotic enteritis, 20 were cured and 3 ineffecitve. |
| Dysfunctional uterine bleeding |
chao di yu, shu di, huang qi, dang shen, 30g each; chao bai zhu, dang gui, 15g each; pao jiang, e jiao (melted), 10g each; sheng ma 6g. 1 dose every day, water decoction. After 3~9 doses, all treated 32 cases were cured. |
| Skin diseases |
Parched di yu powder and vaseline were made into 30% ointment for external application to treat skin diseases such as eczema and ringworm of the feet, etc.. 109 cases were treated, and 47 cured, 50 markedly effective or effective. |
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| References |
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Except those noted, all references come from Weng Weiliang, et al., Clinical Chinese materia medica, Henan Science & Technology Press, 1998 |
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