Oral administration and intraperitoneal injection of E Zhu Injection to mice had inhibitory effect on S180. Curcumenol had inhibitory effect on S73, U14 and ehrlich carcinoma. E Zhu oil had direct destroying effect on ascites carcinoma and L615 WBC in vitro.

Effect of Rhizoma Curcumate Zedoariae and Rhizoma Sparganii on apoptosis of human lung cancer cell line A549

The object was to study the medhanism of inhibitory and tumor killing effects of two kinds of Chinese traditional herbs, rhizoma Curcumate zeloariae and Rhizoma Sparganii. Lung cancer cell line A549 was adopted as target cell. The research examined tumor cell apoptosis induced by the herbs with flow cytometry when the target cell was cultured with the herb substration for 24h. The substraction both two kinds of herbs can induce tumor cell apoptosis. The great synergic effect to induce target cell apoptosis was also found out. The results suggested that to induce target cells apoptosis is the man mechanism in inhibiting and killing tumor by the herbs.

--Wang Z, Zhang JF, Fu GF. Journal of Capital University of Medical Sciences. 2001; 22(4): 304~5.

in vitro and in vivo tests showed that the mechanism of treating cervical cancer with e zhu lied not only in direct inhibitory and killing effect on cancer cells, but also active immune protecting effect.

Water extract-alcohol precipitation could lower plasma viscosity, whole blood viscosity under low shear rate, and packed cell volume, it could also inhibit platelet aggregation, lower platelet adhesion rate, inhibit in vitro thrombosis and fibrinogen.

e zhu could elevate WBC. Alcohol extractum of e zhu could terminate early pregnancy. It could obviously lower serum T4 in mice. E Zhu Injection could significantly increase the blood volume and lower serum creatinine urea nitrogen in rabbits with acute renal failure induced by glycerin. E Zhu Oil had anti-bacterial and anti-viral effects on some bacteria and viruses.

30 cases of infantile viral enteritis were treated with intravenous drip of 0.04% E Zhu Oil-Glucose Injection at the dosage of 100mg/kg, qd in addition to virazole, 5~7 days as a course of treatment. The curative time and fever-allaying time were both superior to those in the group treated with western medicine only.

E Zhu Oil had inhibitory or killing effect on respiratory syncytial virus, influenza virus A1 and A3, rubella virus, chickenpox virus, etc.. 84 infantile cases of viral infections were randomly divided into E Zhu Oil treated group and control group treated with Ribavirin. Both groups had similar fever-allaying time, and symptom or sign improving time and curative time. There's no significant difference between the two groups.

Water solution of E Zhu Volatile Oil, 10~30ml for local injection, accompanied with intravenous drip. After around 15 days, local necrosis was seen in the affected area. The side effects included pain and vertigo, etc..

Sterilized cotton ball with E Zhu Ointment (each kg containing 40ml volatile oil) was placed in the affected area of cervical erosion, once daily. The effective rate was over 90%.

Except those noted, all references come from Weng Weiliang, et al., Clinical Chinese materia medica, Henan Science & Technology Press, 1998