Gou Qi Zi - Lycium chinense

Professional Data
 Pin Yin
Gou Qi Zi
 
 Latin
Fructus Lycii
 Introduction Back to Top
Barbary Wolfberry Fruit is the dried ripe fruit of Lycium barbarum L. (Fam. Solanaceae). The drug is collected in summer and autumn when the fruit turns orange-red. After drying in the shade to make the pericarp shrunken, the drug is exposed to strong sun light until the exocarp is dried and hard, and the pulp soft, removed from the fruit stalk.

 Western medical Back to Top
This herb is indicated in the treatment of chronic atrophic gastritis, male sterility, obesity, hyperlipoidemia, chronic hepatitis, hepatocirrhosis, primary liver cancer, furuncle, bedsore, etc..

 Eastern medical Back to Top
  • Pattern: Supplements Essence and Blood, tonifies the Liver and the Kidney, brightens the eyes.
  • Properties: Sweet, neutral.
  • Channels Entered: Liver, Kidney.
 Chemical constituents Back to Top
The main constituent of barbary wolfberry fruit is bataine, Others include zeaxanthin, physalein, thiamine, lactoflavin, carotene, nicotinic acid, etc..

 Pharmacological actions Back to Top
Promoting and regulating functions on immunity

gou qi can increase the function of non-specific immunity, it can obviously increase the phagocytic ability of reticuloendothelial system in mice, the phagocytosis percentage and index of phagocytes, serum lysozyme activity and valence of antibody onload="highlight();" , etc..

Antiaging effect

Lysozyme activity, IgG, IgA and lymphocyte transformation rate could all be obviously increased in senile volunteers after they took gou qi at the dosage of 50g/day for 10 days, and the increasing of cAMP showed statistic significance, cGMP decreased obviously which made the ratio of cAMP/cGMP rose again, the level of testosterone increased obviously too.

Effects of lowering blood fat and protecting the liver

gou qi can lower the cholesterol in the blood of rat. It can promote the regeneration of liver cells.

Lowering blood sugar effect

Subcutaneous injection of gou qi extract at the dosage of 6g/kg can decrease the blood sugar of rabbits by 13% within 2~3 hours, then the sugar level will return gradually. Extracts of Nin Xia gou qi can lower the blood sugar of rats obviously and persistently and increase the sugar tolerance.

Influence over the blood system

Administration through gastrogavage of 0.5ml 10% gou qi decoction in normal mice for successive 10 days could promote the hematopoiesis and increase the numbers of white blood cells and lymphocytes. gou qi can also promote the generation of RBC and hemoglobin, and elevate platelets.

Anti-cancer function

Combined with cyclophosphamide, gou qi showed better inhibitory effect on tumor weight of W256 than that of single application of cyclophosphamide, in addition, it could relieve leukopenia caused by cyclophosphamide. gou qi had an inhibitory rate of 42% on S180 in mice, and it didn't show obvious inhibitory effect on other transplanted tumor. Single employment of gou qi didn't show obvious anticancer effect. In vitro, it showed inhibitory effect on cultured strain of human cervical cancer cell JTC-26.

Others

Water extract of gou qi can lower blood pressure, inhibit the heart, excite the intestine. Its decoction can excite isolated uterus, water extract has estrogen-like function that shows weight-increasing function on uterus.

 Clinical Studies Back to Top
Chronic atrophic gastritis

gou qi was made into powder after being cleaned and dried, 20g every day, take the drug in two times after chewing, 2 months as a course of treatment. 20 cases were treated, 15 were markedly effective, 5 effective.

Male sterility

15g gou qi was taken after chewing every night, 1 month as a course of treatment. Continue another one month after routine semen examination showed a normal result. 42 cases were treated, and semen examination turned normal in 33 patients which all had offspring later.

Obesity

gou qi 30g every day, take it with water in the morning and evening, 5 cases were treated. After 4 months' treatment, the body onload="highlight();" weights of them returned to normal range.

Hyperlipoidemia

Jiang Zhi Granule (gou qi, nu zhen zi, brown sugar) was taken 30 minutes after meal, twice every day, 4~6 weeks as a course of treatment. 406 cases were treated. The results showed that this herb had very significant therapeutic effect on various type of hyperlipoidemia (P<0.01). Its triglyceride-lowering and b-lipoprotein-lowering effects were similar to those of clofibrate, its cholesterol-lowering effect was better than that of clofibrate, but without the adverse effects of the latter.

Vomiting of pregnancy

gou qi 50g, huang qin 50g were soaked in boiling water, drink the water when it becomes cooler. 200 cases of vomiting of pregnancy were treated, the effective rate was 95%.

 
 References Back to Top

Except those noted, all references come from Weng Weiliang, et al., Clinical Chinese materia medica, Henan Science & Technology Press, 1998