 Pin Yin
|
|
Gua Di
|
| |
| Latin
|
|
Calyx Cucumis
|
|
|
|
| Introduction |
Back to Top |
Calyx Cucumis is the fruit stalk of Cucumis melo L (Fam. Cucurbitaceae). The drug is collected in every June to July by picking and cutting the stalk of immature fruits, then drying in the shade.
|
| Western medical |
Back to Top |
The drug is used to promote emesis and treat acute hepatitis, etc..
|
| Eastern medical |
Back to Top |
- Pattern: Promotes vomiting, treats jaundice and discharges Fire.
- Properties: Bitter, cold, toxic.
- Channels entered: Spleen and Stomach.
|
| Chemical constituents |
Back to Top |
gua di contains elaterin, sterol, saponins and amino acids. It also contains cucurbitacine B, E and D, etc..
|
| Pharmacological actions |
Back to Top |
| Anti-hepatitis effect |
Cucurbitacine B could significantly lower GPT in rats with experimental acute CCl4 poisoning. It could obviously increase the accumulation of hepatic glycogen so as to prevent liver cell degeneration and inhibit hepatic fibrosis. |
| Anti-tumor effect |
Animal in vivo tests showed that cucurbitacine B had inhibitory effect on the growth of sarcoma S180. It could prolong the survival time of animals with Scehrich tumor. in vitro tests showed that it had cytotoxin on human nasopharyngeal cancer and Hela cancer. |
| Influence over the gastrointestinal tract |
Melotoxin administrated to experimental animals could cause vomiting and diarrhea, but intradermal or intravenous injection wouldn't induce these reactions.
|
|
| Clinical Studies |
Back to Top |
| Acute infectious hepatitis with jaundice |
Dried gua di 5g was made into gua di fluid which was taken after meals, bid~tid. 103 cases of acute infectious hepatitis with jaundice wre treated, and 46.5% was cured within 10 days, 92.2% were cured within 15 months. |
|
|
| |
| References |
Back to Top |
Except those noted, all references come from Weng Weiliang, et al., Clinical Chinese materia medica, Henan Science & Technology Press, 1998 |
|
