The water soluble part of gui jian yu could improve anoxia tolerance in mice. Under anoxic conditions, it could increase the survival rate and lengthen the survival time of mice.

The water soluble part of gui jian yu could increase the contracting amplitude of frog heart, increase its output and slightly quicken the heart rate. The effect was especially obvious in the condition of heart failure, but increasing the dosage would have an opposite effect, and the heart would stop in the diadtolic phase. It also had protecting effect on acute myocardial ischemia induced by pituitrin in rats and Guinea pigs. It could alleviate the arrhythmia T wave change induced by injection of KCl in Guinea pigs.

Intravenous injection of gui jian yu in femoral vein could increase the blood flow amount and decrease the resistance of coronary artery, lower oxygen consumption and improve ischemic condition in the cardiac muscle. Small dosage injection into femoral artery could dilate distal vessels, lower the resistance of distal vessels and increase blood flow amount.

Intravenous injection of gui jian yu preparation could rapidly lower the blood pressure of cat, rabbit and dog within 1 minute, and within 5 minutes, the blood pressure could be restored to original level.

Water decoction of gui jian yu could lower serum total cholesterol, increase HDL2-C, obviously lower HDL3-C, and increase the activity of LCAT. It could delay the formation of atherosclerosis.

Sodium oxaloacetic acid extracted from gui jian yu decoction could lower blood sugar and urine sugar, and increase body onload="highlight();" weight in normal rabbits or rabbits with diabetes induced by alloxan. For normal anaesthesized dog, intravenous drip could obviously lower the blood sugar.

The water soluble part of gui jian yu had sedative effect on mice, the effect was obvious when the dosage increased. It could also obviously increase the central inhibitory effect of pentobarbitale sodium and thiopentone sodium.

1,2:5,6-dianhydrogalactitol had certain curative effect on lung cancer, adrenal cancer, bladder cancer, laryngeal carcinoma and neuroglioma. Dianhydrogalactitol had therapeutic effect on leukemia.

Gui Jian Yu syrup, oral administration, 10~15ml, three times daily. 103 cases of pectoris angina of coronary heart disease were treated, and the effective rate was 84.2%, the ECG effective rate was 65.2%.

yu xing cao, bai jiang cao, da suan, gui jian yu, huang qin and dan shen were made into Qing Luo Injection, each ml liquid was equal to 65g crude drug. 36 cases of acute attach of pulmonary heart disease were treated, 16 were markedly effective, 17 improved and 3 ineffective.

chai hu 240g; xia ku cao 300g; shan ci gu, chen pi, gui jian yu, ban xia, tu bei mu, hai zao, kun, 200g each were made into granules. 30g each time, three times daily, 1 month as a course of treatment. 115 cases of thyroid nodule were treated, and 98 were effective.

Chuan Xiao Tang (ting li zi 15g, gui jian yu 15g, qing pi 10g, chen pi 10g, bing lang 10g, mu jing zi 15g, sheng da huang 10g, sheng jiang 10g) was used to treat 30 cases of acute attach of asthma. 1 dose every day, taken in three times daily for 7 consecutive days. The total clinical effective rate was 93.33%.

Huo Xue Hua Yu Fang: gui jian yu, hua fen, sheng di, huang qi, 20g each; zi lan, chuan xiong, chi shao, di gu pi, 15g each; dan shen 30g; shui zhi 10g, 1 dose every day, water decoction, 3 months as a course of treatment. 30 cases were markedly effective, 19 improved and 8 ineffective, the total effective rate was 86%.

gui jian yu 6g (3g for children), 10g hong hua would be combined usually. The formula was used to treat 21 cases of chronic active hepatitis, after 1~2 months, 14 cases were markedly effective, 6 improved and 1 ineffective.

Except those noted, all references come from Weng Weiliang, et al., Clinical Chinese materia medica, Henan Science & Technology Press, 1998