This herb exhibits a significant anti-neoplastic effect against P-388 leukemia bearing mice, very effective in the treatment against late stage ovarian cancer. It increases survival rate of patients suffering from metastatic breast cancer

Paclitaxe (Taxol), the active ingredient contained in hong dou shan had significant inhibitory effect on transplanted breast cancer, brain cancer, lung caner, L1210, P388, P1534, B16, W256 and Lewis lung cancer.

Multidrug resistant cancer cells susceptibility to cytotoxic taxane diterpenes from Taxus yunnanensis and Taxus chinensis.

Twelve taxane diterpenes (1-12), which were isolated previously from the EtOH extract of the aerial parts of Taxus yunnanensis or Taxus chinensis, were evaluated for cytotoxicity against the multidrug resistant cancer cells KB-VIN and KB-7d. Compounds and showed significant cytotoxicity in these cell lines. Compounds and also demonstrated significant activity against KB-7d. The biflavonoid isolated from T. yunnanensis was only marginally cytotoxic against the A549 (lung) cell line, but a simple methoxylated analogue (14) was inactive.

--Shinozaki Y, Fukamiya N, Uchiyama C, Okano M, Tagahara K, Bastow KF, Lee KH. Bioorg Med Chem Lett. 2002 Oct 7;12(19):2785-8.

Paclitaxe could regulate body onload="highlight();" immune function, and have effect on TNF receptor located on macrophages, and stimulate the release of TNF-a, IL-1, IL-2, IL-6, IFN-2, IFN-b which could kill and inhibit tumor cells.

Paclitaxe had good therapeutic effect on oophoroma and breast cancer. It also had therapeutic effect on prostatic cancer, cancers of upper gastrointestinal tract and lung cancers.

Except those noted, all references come from Weng Weiliang, et al., Clinical Chinese materia medica, Henan Science & Technology Press, 1998