lu lui had the strongest stimulative effect in all laxatives of rheochrysin, it could cause obvious abdominal pain and pelvic congestion. In severe cases, it could result in nephritis.

lu hui could promote the heal of trauma. Its extract or ointment had slight protective effect on local X-radiation in mcie.

1:500 alcohol infusion of lu hui could in vivo inhibit the growth of S180 and ehrlich carcinoma.

Anti-leukaemic and anti-mutagenic effects of di(2-ethylhexyl)phthalate isolated from Aloe vera Linne.

Extracts of Aloe vera Linne have been found to exhibit cytotoxicity against human tumour cell lines. This study examines the anti-tumour effects of di(2-ethylhexyl)phthalate (DEHP) isolated from Aloe vera Linne, in human and animal cell lines. Its anti-mutagenic effects were examined using Salmonella typhimurium TA98 and TA100 strains. Growth inhibition was specifically exerted by DEHP against three leukaemic cell lines at concentrations below 100 microg mL(-1). At 100 microg mL(-1) DEHP, K562, HL60 and U937 leukaemic cell lines showed growth inhibition of 95, 97 and 95%, respectively. DEHP exhibited an inhibitory activity of 74, 83 and 81%, respectively, in K562, HL60 and U937 cell lines at a concentration of 10 microg mL(-1). At a concentration of 1 microg mL(-1), DEHP exerted an inhibitory activity of 50, 51 and 52%, respectively, in K562, HL60 and U937. In a normal cell line, MDBK, DEHP exerted 30% growth inhibition at a concentration of 100 microg mL(-1), and showed no inhibitory activity at concentrations below 50 microg mL(-1). It was found that DEHP exerted anti-mutagenic activity in the Salmonella mutation assay. The number of mutant colonies of Salmonella typhimurium strain TA98 upon exposure to AF-2 (0.2 microg/plate) decreased in a concentration-dependent manner in the presence of different DEHP concentrations (decreasing to 90.4, 83.9, 75.4, 69.6 and 46.9%, respectively, for DEHP concentrations of 100, 50, 10, 5 and 1 microg/plate). In the case of Salmonella typhimurium strain TA100, DEHP reduced AF-2-induced mutagenicity at 1, 5, 10, 50 and 100 microg/plate to 57.4, 77.5, 80.0, 89.0 and 91.5%, respectively. The isolated compound from Aloe vera Linne, DEHP, was considered to be the active principle responsible for anti-leukaemic and anti-mutagenic effects in-vitro.

--Lee KH, Kim JH, Lim DS, Kim CH. J Pharm Pharmacol. 2000 May; 52(5): 593-8.

1:500 extract of lu hui had inhibitory effect on isolated toad's hearts. Water infusion could inhibit some dermatomyces in vitro to different degrees.

Lu Hui Injection, each ml containing 0.1g crude drug, 4ml i.m., 2 months as a course of treatment. 38 cases were cured and the therapeutic effect was 86.8%.

lu hui was made into injection each ml of which contained 2g crude drug, 2ml, i.m., once daily, 30 days as a course of treatment with an interval of 7 days. In the second course, 4ml, i.m. once daily. 18 cases were treated, and 9 were markedly effective, 7 improved, 2 ineffective.

Dizziness, headache, tinnitus, deafness, irritability and constipation were treated with Dang Gui Lu Hui Wan, 3~6g daily, 1~2 times daily.

Except those noted, all references come from Weng Weiliang, et al., Clinical Chinese materia medica, Henan Science & Technology Press, 1998