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Mu Xiang - Aucklandia Lappa
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Professional Data |
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 Pin Yin
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Mu Xiang
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| Latin
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Radix Auklandiae lappae
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| Introduction |
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Radix Auklandiae lappae is the dried root of Aucklandia lappa Decne. (Fam. Compositae) The drug is collected in winter and spring, removed from soil and rootlets, cut into section, and the large one further longitudinally cut into pieces, dried, and removed from the rough outer bark by dashing.
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| Western medical |
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The herb is indicated in the treatment of biliary colic, ileus and peptic ulcer, etc..
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| Eastern medical |
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- Pattern: Moves qi, alleviates pain.
- Properties: Acrid, bitter, warm.
- Channels entered: Spleen, Stomach, Large Intestine and Gallbladder.
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| Chemical constituents |
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The herb contains volatile oil including ¦Á- and ¦Â-costene, costuslactone, dihydrocostuslactone, costuslactone, costic acid and costol, etc.. The other ingredients include resin and synanthrin, etc..
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| Pharmacological actions |
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| Effects on digestive system |
mu xiang could promote gastric emptying. |
| Effects on in vivo bowel movement |
mu xiang decoction could increase in vivo enterokinesia in rabbits, as well as contracting amplitude and frequency of intestinal muscle. Its volatile oil and costuslactone could inhibit isolated bowel movement in rabbits. |
| Effects on bile stone |
mu xiang 25g, zhi ke 15g, yan hu 25g, jin qian cao 50g, zhi zi 20g, da huang 25g (decocted later), 5ml for gastrogavage, qd, for consecutive 30 days. It could significantly reduce the weight of bile stone put in the gallbladders of rabbits, and the formation rate of new stone was less than that of the control group. |
| Effects on cardiovascular system |
The volatile oil of mu xiang and costuslactone could inhibit the activity of isolated heart of rabbits, guinea pigs and frogs. Water and ethanol extract of mu xiang could excite in vivo frog and dog heart at low dosage, and had inhibitory effect at large dosage. |
Intravenous injection of water and ethanol extract of mu xiang to anaesthetized dogs could mildly elevate blood pressure. But the intravenous injection of its volatile oil and costuslactone had medium hypotensive effect. |
| Other effects |
Volatile oild of mu xiang at the concentration of 1:3000 could inhibit streptococcus and staphylococcus aureus. mu xiang decoction had inhibitory effect on bacillus paratyphosus and fungi. Water docotion of mu xiang had inhibitory effect on platelet aggregation.
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| Clinical Studies |
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| Biliary colic |
mu xiang 10g, da huang 15g. 300ml boiled water was added to soak the drugs for 10 minutes, and drink the water frequently. 21 cases of biliary colic were relieved, 20 effective and 4 ineffective. |
| Adhesive ileus |
mu xiang, zhi ke, chi shao, yan hu, chuan lian zi, yu li ren, sheng da huang (decocted later), mang xiao, 5g each; chuan po, huang bo, chao lai fu zi, gan cao, 3g each; dang gui 6g; gua lou 10g, 1 dose every day, through stomach tube. Supporting treatment was applied. 30 cases were cured, 3 ineffective. |
| Peptic ulcer |
mu xiang, wu ling zi, chai hu, yan hu, gan cao, bai ji and proper amount of NaHCO3 were makde into tablets. 3~5 tablets, tid, half an hour before meals, 4 weeks as a course of treatment. Among 50 treated cases, 31 were cured, 16 improved and 3 ineffective. |
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| References |
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Except those noted, all references come from Weng Weiliang, et al., Clinical Chinese materia medica, Henan Science & Technology Press, 1998 |
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