Coixenolide had inhibitory effect on Ehrlich carcinoma cells. Intraperitoneal injection of ethanol extract of yi yi ren had inhibitory effect on Ehrlich carcinoma of mice, and could lengthen the survival time of animals. Acetone extract of yi yi ren had obvious inhibitory effect on mice cervical cancer-14 (U-14) and HCA solid tumor.

1. Interventional therapy combining Seed of Job's-tears with lipiodol for hepatoma-bearing rats

OBJECTIVE: To study the effect of the interventional therapy of hepatoma-bearing rat by Seed of Job's-tears (SJT) injection combining with lipiodol. METHODS: To evaluate the effect of SJT as a medicament which can be used in interventional therapy, we repeated the hepatoma-bearing rats, and treated them by interventional therapy with SJT referring to the method which Lindel set up, comparing its effect to which of chemical medicines and lipiodol. RESULTS: SJT or lipiodol alone had an inhibiting effect to liver cancer. The tumor growth rates were 13.89%, 14.05%, and the tumor inhibiting rates reached 38.10%, 37.49%. The curative effect of the SJT/lipiodol group was the best, and its growth rate and inhibiting rate were 3.36% and 85.03%, respectively better than the SJT group and lipiodol group (P<0.01). There was no statistically significant difference between the effect of the SJT/lipiodol group and the mitomycin/lipiodol group. The survival period of SJT/lipiodol group was longer than the rest groups (P<0.01 or P<0.05). CONCLUSIONS: The interventional therapy by SJT/lipiodol has obvious inhibitory effect on the growth of hepatoma-bearing rats, which is similar to that of MMC/lipiodol. This inhibiting effect is better than that of the SJT or lipiodol group. SJT/lipiodol can prolong the survival period of hepatoma-bearing rats obviously, and this effect is better than that of single lipiodol, SJT or MMC/lipiodol.

--Huang T, Wu W, Li Y, Zhang J, Huang L. Zhonghua Gan Zang Bing Za Zhi. 2002 Dec;10(6):452-4.

yi yi ren decoction could increase the tension and amplitude of uterus of rabbits and guinea pigs. Fatty oil of yi yi ren could excite the respiration at small dosages, but could anaesthetize the respiration at large dosages. Coixolalso had analgesic, anti-febrile, blood pressure lowering and blood sugar lowering effects.

sheng yi yi ren 10g, gan cao 3g, water decoction, 1 dose daily; or 100g decocted with rice daily. The method could be used to treat warts over the body onload="highlight();" .

Yi Yi Ren Syrup (100ml was equal to 50g crude drug), oral administration, 20~40ml, 3 times daily. It was used to treat lung cancer , intestinal cancer, stomach cancer, cervical cancer, etc.. yi yi ren ombined with teng liu, he zi an ling jiao was used to treat alimentary tract cancers. 168 cases of patients were treated, 1 dose every day, taken in three times. After treatment, the appetite and general condition were improved. And this formula had certain therapeutic effects on 30 cases out of 36 cases who took over three months' treatment.

yi yi ren, shan yao, bian dou, qian shi, bi xie and shi chang pu of equal amount were grounded into powder, 15g daily, taken with water. Modify the formula according to accompanied symptoms. Among 43 treated cases of chyluria, 40 were cured and 3 ineffective.

sheng yi yi ren 30~60g, shu fu pian 5~10g, bai jiang cao 15~30g, water decoction. The dregs mixed with scallion and salt, 30g each were fried to warm with distilled spirit for external application. The method would take effect on ovary cyst after 23~65 days' treatment.

sheng yi yi ren 30g and bian xu cao 30g were decocted with 500ml water, 1 dose daily. 46 out of 50 treated hydrocele were effective.

Except those noted, all references come from Weng Weiliang, et al., Clinical Chinese materia medica, Henan Science & Technology Press, 1998