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Zhi Ke - Citrus aurantium
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Professional Data |
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 Pin Yin
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Zhi Ke
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| Latin
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Fructus Citri aurantii
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| Introduction |
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Fructus Citri aurantii is the dried, ripe fruit of Citrus aurantiu L. and its cultivated varieties (Fam. Rutaceae). The drug is collected in September and October when the fruit is nearly ripe. Cut in the middle into two parts, dried in the sun or at a low temperature.
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| Western medical |
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The herb is indicated in the treatment of hysteroptosis, hepatic and splenic flexure syndrome, etc..
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| Eastern medical |
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- Pattern: Moves qi, broadens the Center, eliminates distension and fullness.
- Properties: Bitter, mildly cold.
- Channels entered: Spleen, Stomach and Large Intestine.
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| Chemical constituents |
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The herb contains volatile oil, and its main ingredients includes limonene and linalool. The other constituents are flavones including hesperidin, naringin, synephrine and N-methyltyramine.
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| Pharmacological actions |
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| Effect of elevating blood pressure |
Zhi Shi Injection could obviously elevate blood pressure in anesthetized dogs, and the effective ingredients were synephrine and N-methyltyramine. |
| Effects on the heart |
Zhi Shi Injection could increase heart rate slightly in anesthetized dogs. |
| Effects on gastrointestinal smooth muscle |
Decoction of zhi shi and zhi qiao could excite gastrointestinal smooth muscle. |
| Effects on the uterus |
zhi ke could excite uterus in vitro of unpregnant and early-pregnant rabbits. |
| Other effects |
zhi shi had cardiotonic effect on isolated heart, it also had diuretic and anti-allergic effects. It could inhibit helicobacter pylori and the inhibition zone was 19mm.
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| Clinical Studies |
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| Hysteroptosis |
zhi ke 15g and chong wei zi 15g were made into 100ml decoction, once every day, 1 month as a course of treatment. 924 cases of hysteroptosis I were treated, 602 cases were markedly effective, 173 effective and 149 ineffective. |
| Hepatic and splenic flexure syndrome |
mu xing, hou po, da fu pi, bing lang, lai fu zi, zhi ke, 30g each; chen xiang 15g. 1 dose every day, water decoction. The symptoms were relieved after 3 days and disappeared after 7 days.
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| Notes |
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Zhi Ke and Zhi Shi are from the same plant. Zhi Shi is the immature fruit, collected in July when the fruit is green yet. They have similar functions, but Zhi Shi's are stronger. Most research is targeted at Zhi Shi.
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| References |
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Except those noted, all references come from Weng Weiliang, et al., Clinical Chinese materia medica, Henan Science & Technology Press, 1998 |
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